MGP Database

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MGP004820

UniProt Annotations

Entry Information
Gene NameF-box and WD repeat domain containing 2
Protein EntryFBXW2_HUMAN
UniProt IDQ9UKT8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UKT8-1; Sequence=Displayed; Name=2; Synonyms=MD6b; IsoId=Q9UKT8-2; Sequence=VSP_012983;
FunctionSubstrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex.
InteractionQ16543:CDC37; NbExp=2; IntAct=EBI-914727, EBI-295634; P08238:HSP90AB1; NbExp=2; IntAct=EBI-914727, EBI-352572; Q9Y266:NUDC; NbExp=2; IntAct=EBI-914727, EBI-357298; P63208:SKP1; NbExp=3; IntAct=EBI-914727, EBI-307486;
Sequence CautionSequence=AAF04465.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAF13226.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAP97276.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=AAP97280.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305};
SimilarityContains 1 F-box domain. {ECO:0000255|PROSITE- ProRule:PRU00080}.
SimilarityContains 4 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
SubunitDirectly interacts with SKP1 and CUL1. {ECO:0000269|PubMed:10531035}.
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