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MGP004842

Record overview

MGPD IDMGP004842
Gene ID26279
SpeciesHomo sapiens (Human)
Gene Namephospholipase A2, group IID
Gene Symbol PLA2G2D
SynonymsSPLASH; sPLA2S; PLA2IID; sPLA2-IID;
Alternate namesgroup IID secretory phospholipase A2; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholipase A2s; secretory-type PLA, stroma-associated homolog;
Chromosome1
Map Location1p36.12
EC Number3.1.1.4
SummaryThis gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
OrthologsView orthologs and multiple alignments for PLA2G2D

Proteins

group IID secretory phospholipase A2 isoform 1 precursor
Refseq ID:NP_036532
Protein GI:6912596
UniProt ID:Q9UNK4
mRNA ID:NM_012400
Length:145
RefSeq Status:
MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDK
GSWCEQQLCACDKEVAFCLKRNLDTYQKRLRFYWRPHCRGQTPGC
 
sig_peptide: 1..20
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q9UNK4.2)
calculated_mol_wt: 2028
peptide sequence: 
MELALLCGLVVMAGVIPIQG

mat_peptide: 21..62
product: group IID secretory phospholipase A2 isoform 2
calculated_mol_wt: 4551
peptide sequence: 
GILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDC

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2028
peptide sequence: 
MELALLCGLVVMAGVIPIQG

mat_peptide: 21..145
product: Group IID secretory phospholipase A2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9UNK4.2)
calculated_mol_wt: 14537
peptide sequence: 
GILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDWCCQTHDCCYDHLKTQGCSIYKDYYRYNFSQGNIHCSDKGSWCEQQLCACDKEVAFCLK
RNLDTYQKRLRFYWRPHCRGQTPGC
 
group IID secretory phospholipase A2 isoform 2 precursor
Refseq ID:NP_001258743
Protein GI:425854812
UniProt ID:Q9UNK4
mRNA ID:NM_001271814
Length:62
RefSeq Status:
MELALLCGLVVMAGVIPIQGGILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDC
 
sig_peptide: 1..20
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q9UNK4.2)
calculated_mol_wt: 2028
peptide sequence: 
MELALLCGLVVMAGVIPIQG

mat_peptide: 21..62
product: group IID secretory phospholipase A2 isoform 2
calculated_mol_wt: 4551
peptide sequence: 
GILNLNKMVKQVTGKMPILSYWPYGCHCGLGGRGQPKDATDC
 
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