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MGP004842

UniProt Annotations

Entry Information
Gene Namephospholipase A2, group IID
Protein EntryPA2GD_HUMAN
UniProt IDQ9UNK4
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimally active at neutral to alkaline pHs with 2 mM Ca(2+).;
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.
SimilarityBelongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000305}.
Tissue SpecificityBroadly expressed.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g2d/";
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