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MGP004907

Record overview

MGPD IDMGP004907
Gene ID27040
SpeciesHomo sapiens (Human)
Gene Namelinker for activation of T cells
Gene Symbol LAT
SynonymsLAT1; pp36;
Alternate nameslinker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; linker for activation of T cells, transmembrane adaptor; p36-38;
Chromosome16
Map Location16p11.2
SummaryThe protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for LAT

Proteins

linker for activation of T-cells family member 1 isoform a
Refseq ID:NP_055202
Protein GI:7657293
UniProt ID:O43561
mRNA ID:NM_014387
Length:262
RefSeq Status:
MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRD
SDGANSVASYENEGASGIRGAQAGWGVWGPSWTRLTPVSLPPEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDY
VNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN
 
linker for activation of T-cells family member 1 isoform b
Refseq ID:NP_001014987
Protein GI:62739155
UniProt ID:O43561
mRNA ID:NM_001014987
Length:233
RefSeq Status:
MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRD
SDGANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHP
GAAKTEPAALSSQEAEEVEEEGAPDYENLQELN
 
linker for activation of T-cells family member 1 isoform c
Refseq ID:NP_001014988
Protein GI:62739157
UniProt ID:O43561
mRNA ID:NM_001014988
Length:232
RefSeq Status:
MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPSPQPLGGSHRTPSSRRDS
DGANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPG
AAKTEPAALSSQEAEEVEEEGAPDYENLQELN
 
linker for activation of T-cells family member 1 isoform d
Refseq ID:NP_001014989
Protein GI:239049118
UniProt ID:O43561
mRNA ID:NM_001014989
Length:269
RefSeq Status:
MEATAASWQVAVPVLGGASRPLGPRGAASLLRAPLQMEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSLYPRGIQFKRPHTVAPWPPAY
PPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRDSAFS
MESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEVEEEGAPDYENLQELN
 
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