MGP Database

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MGP004909

Record overview

MGPD IDMGP004909
Gene ID27068
SpeciesHomo sapiens (Human)
Gene Namepyrophosphatase (inorganic) 2
Gene Symbol PPA2
SynonymsHSPC124; SID6-306;
Alternate namesinorganic pyrophosphatase 2, mitochondrial; PPase 2; pyrophosphatase SID6-306; pyrophosphate phospho-hydrolase 2;
Chromosome4
Map Location4q25
EC Number3.6.1.1
SummaryThe protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PPA2

Proteins

inorganic pyrophosphatase 2, mitochondrial isoform 1 precursor
Refseq ID:NP_789845
Protein GI:29171702
UniProt ID:Q9H2U2
mRNA ID:NM_176869
Length:334
RefSeq Status:
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPR
WTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSCGEVIHVKILGILALIDEGET
DWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF
RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
 
transit_peptide: 1..31
calculated_mol_wt: 3100
peptide sequence: 
MSALLRLLRTGAPAAACLRLGTSAGTGSRRA

mat_peptide: 32..232
product: inorganic pyrophosphatase 2, mitochondrial isoform 3
calculated_mol_wt: 22910
peptide sequence: 
MALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEA
TLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLG
K

transit_peptide: 1..31
calculated_mol_wt: 3100
peptide sequence: 
MSALLRLLRTGAPAAACLRLGTSAGTGSRRA

mat_peptide: 32..168
product: inorganic pyrophosphatase 2, mitochondrial isoform 4
calculated_mol_wt: 15834
peptide sequence: 
MALYHTEERGQPCSQNYRLFFNIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISD
SPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK

transit_peptide: 1..31
calculated_mol_wt: 3100
peptide sequence: 
MSALLRLLRTGAPAAACLRLGTSAGTGSRRA

mat_peptide: 32..305
product: inorganic pyrophosphatase 2, mitochondrial isoform 2
calculated_mol_wt: 31576
peptide sequence: 
MALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVAN
IFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKN
KAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK

transit_peptide: 1..31
calculated_mol_wt: 3100
peptide sequence: 
MSALLRLLRTGAPAAACLRLGTSAGTGSRRA

mat_peptide: 32..334
product: inorganic pyrophosphatase 2, mitochondrial isoform 1
calculated_mol_wt: 34839
peptide sequence: 
MALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVAN
IFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYL
EATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHF
LGK
 
inorganic pyrophosphatase 2, mitochondrial isoform 2 precursor
Refseq ID:NP_008834
Protein GI:77812678
UniProt ID:Q9H2U2
mRNA ID:NM_006903
Length:305
RefSeq Status:
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPR
WTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPG
YLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW
HFLGK
 
transit_peptide: 1..31
calculated_mol_wt: 3100
peptide sequence: 
MSALLRLLRTGAPAAACLRLGTSAGTGSRRA

mat_peptide: 32..232
product: inorganic pyrophosphatase 2, mitochondrial isoform 3
calculated_mol_wt: 22910
peptide sequence: 
MALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEA
TLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLG
K

transit_peptide: 1..31
calculated_mol_wt: 3100
peptide sequence: 
MSALLRLLRTGAPAAACLRLGTSAGTGSRRA

mat_peptide: 32..168
product: inorganic pyrophosphatase 2, mitochondrial isoform 4
calculated_mol_wt: 15834
peptide sequence: 
MALYHTEERGQPCSQNYRLFFNIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISD
SPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK

transit_peptide: 1..31
calculated_mol_wt: 3100
peptide sequence: 
MSALLRLLRTGAPAAACLRLGTSAGTGSRRA

mat_peptide: 32..305
product: inorganic pyrophosphatase 2, mitochondrial isoform 2
calculated_mol_wt: 31576
peptide sequence: 
MALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVAN
IFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKN
KAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
 
inorganic pyrophosphatase 2, mitochondrial isoform 3 precursor
Refseq ID:NP_789842
Protein GI:77812680
UniProt ID:Q9H2U2
mRNA ID:NM_176866
Length:232
RefSeq Status:
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEILSCGEVIHVKILGILALIDEGETDW
KLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRC
TQEEARSLVESVSSSPNKESNEEEQVWHFLGK
 
transit_peptide: 1..31
calculated_mol_wt: 3100
peptide sequence: 
MSALLRLLRTGAPAAACLRLGTSAGTGSRRA

mat_peptide: 32..232
product: inorganic pyrophosphatase 2, mitochondrial isoform 3
calculated_mol_wt: 22910
peptide sequence: 
MALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEA
TLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLG
K
 
inorganic pyrophosphatase 2, mitochondrial isoform 4 precursor
Refseq ID:NP_789843
Protein GI:77812682
UniProt ID:Q9H2U2
mRNA ID:NM_176867
Length:168
RefSeq Status:
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFNIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALE
VIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
 
transit_peptide: 1..31
calculated_mol_wt: 3100
peptide sequence: 
MSALLRLLRTGAPAAACLRLGTSAGTGSRRA

mat_peptide: 32..232
product: inorganic pyrophosphatase 2, mitochondrial isoform 3
calculated_mol_wt: 22910
peptide sequence: 
MALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEA
TLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLG
K

transit_peptide: 1..31
calculated_mol_wt: 3100
peptide sequence: 
MSALLRLLRTGAPAAACLRLGTSAGTGSRRA

mat_peptide: 32..168
product: inorganic pyrophosphatase 2, mitochondrial isoform 4
calculated_mol_wt: 15834
peptide sequence: 
MALYHTEERGQPCSQNYRLFFNIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISD
SPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
 
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