MGP Database

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MGP004909

UniProt Annotations

Entry Information
Gene Namepyrophosphatase (inorganic) 2
Protein EntryIPYR2_HUMAN
UniProt IDQ9H2U2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9H2U2-1; Sequence=Displayed; Name=2; IsoId=Q9H2U2-2; Sequence=VSP_011651; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q9H2U2-3; Sequence=VSP_011652; Name=4; IsoId=Q9H2U2-4; Sequence=VSP_011649, VSP_011650; Note=No experimental confirmation available.; Name=5; IsoId=Q9H2U2-6; Sequence=VSP_046256; Note=No experimental confirmation available.;
Catalytic ActivityDiphosphate + H(2)O = 2 phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Sequence CautionSequence=AAF29088.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF29088.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAA84701.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91184.1; Type=Erroneous termination; Positions=59; Note=Translated as Tyr.; Evidence={ECO:0000305}; Sequence=BAG59609.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAB66590.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66590.2; Type=Frameshift; Positions=75; Evidence={ECO:0000305};
SimilarityBelongs to the PPase family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000305}.
SubunitHomodimer. {ECO:0000250}.
Tissue SpecificityDetected in brain, gastric carcinoma, lung, ovary, skeletal muscle, umbilical cord blood and a cell line derived from kidney proximal tubule epithelium. {ECO:0000269|PubMed:15210126}.
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