MGP Database

MGP004931

Record overview

MGPD ID	MGP004931
Gene ID	27165
Species	Homo sapiens (Human)
Gene Name	glutaminase 2 (liver, mitochondrial)
Gene Symbol	GLS2
Synonyms	GA; GLS; LGA; hLGA;
Alternate names	glutaminase liver isoform, mitochondrial; L-glutamine amidohydrolase; breast cell glutaminase; glutaminase I; phosphate-activated glutaminase; phosphate-dependent glutaminase;
Chromosome	12
Map Location	12q13.3
EC Number	3.5.1.2
Summary	The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
Orthologs	View orthologs and multiple alignments for GLS2

Proteins

glutaminase liver isoform, mitochondrial isoform 1 precursor

Refseq ID:	NP_037399
Protein GI:	20336214
UniProt ID:	Q9UI32
mRNA ID:	NM_013267
Length:	602
RefSeq Status:

MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATG
LQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCT
VDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYD
FSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVS
ALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES
MV

transit_peptide: 1..14
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q9UI32.2)
calculated_mol_wt: 1591
peptide sequence: 
MRSMKALQKALSRA

mat_peptide: 15..602
product: Glutaminase liver isoform, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9UI32.2)
calculated_mol_wt: 64750
peptide sequence: 
GSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSE
MHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIP
FCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSE
KETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAK
SAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQ
KDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV

glutaminase liver isoform, mitochondrial isoform 3

Refseq ID:	NP_001267725
Protein GI:	526118214
UniProt ID:
mRNA ID:	NM_001280796
Length:	326
RefSeq Status:

glutaminase liver isoform, mitochondrial isoform 4
`MNTWVSAMPRKVIFPLLPTPTPPTSSTKLGVCFRFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPIT GESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPR REGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQ DSYTLSETQAEAAAEALSKENLESMV`

Refseq ID:	NP_001267727
Protein GI:	526118222
UniProt ID:	Q9UI32
mRNA ID:	NM_001280798
Length:	337
RefSeq Status:

glutaminase liver isoform, mitochondrial isoform 4
`MVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAA TLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDN LRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNH LEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV`

Refseq ID:	NP_001267726
Protein GI:	526118241
UniProt ID:
mRNA ID:	NM_001280797
Length:	337
RefSeq Status:

Protein sequence is identical to GI:526118222 (mRNA isoform)