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MGP004931

UniProt Annotations

Entry Information
Gene Nameglutaminase 2 (liver, mitochondrial)
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UI32-1; Sequence=Displayed; Name=2; IsoId=Q9UI32-2; Sequence=VSP_057009, VSP_057010; Note=No experimental confirmation available.;
Catalytic ActivityL-glutamine + H(2)O = L-glutamate + NH(3).
FunctionPlays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. {ECO:0000269|PubMed:20378837}.
InductionUp-regulated by P53 (at protein and mRNA level) under both stressed and non-stressed conditions. {ECO:0000269|PubMed:20378837}.
SimilarityBelongs to the glutaminase family. {ECO:0000305}.
SimilarityContains 2 ANK repeats. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:20378837}.
SubunitInteracts with the PDZ domain of the syntrophin SNTA1. Interacts with the PDZ domain of TAX1BP3. {ECO:0000269|PubMed:11163757}.
Tissue SpecificityHighly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. {ECO:0000269|PubMed:10620514, ECO:0000269|PubMed:20378837}.
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