MGP Database

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MGP004977

Ontology/Pathway Information

Entrez Gene ID28972
Gene Namesignal peptidase complex subunit 1 homolog (S. cerevisiae)
Gene Symbol SPCS1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0030176 IDA:UniProtKBCintegral component of endoplasmic reticulum membrane
GO:0005787 TAS:UniProtKBCsignal peptidase complex
GO:0008233 IEA:UniProtKB-KWFpeptidase activity
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0010467 TAS:ReactomePgene expression
GO:0045047 IBA:GO_CentralPprotein targeting to ER
GO:0006508 TAS:UniProtKBPproteolysis
GO:0050796 TAS:ReactomePregulation of insulin secretion
GO:0006465 IBA:GO_CentralPsignal peptide processing
GO:0006614 TAS:ReactomePSRP-dependent cotranslational protein targeting to membrane
GO:0006412 TAS:ReactomePtranslation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_71Gene Expression
REACT_23974Incretin synthesis, secretion, and inactivation
REACT_17015Metabolism of proteins
REACT_160078Peptide hormone metabolism
REACT_115902SRP-dependent cotranslational protein targeting to membrane
REACT_19189Synthesis, secretion, and deacylation of Ghrelin
REACT_24019Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_23824Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
REACT_1014Translation
SMP Pathway Links
SMP IDDescription
SMP00174Biotinidase Deficiency
SMP00066Biotin Metabolism
SMP00564Multiple carboxylase deficiency, neonatal or early onset form
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