MGP Database

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MGP004977

UniProt Annotations

Entry Information
Gene Namesignal peptidase complex subunit 1 homolog (S. cerevisiae)
Protein EntrySPCS1_HUMAN
UniProt IDQ9Y6A9
SpeciesHuman
Comments
Comment typeDescription
FunctionComponent of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.
InteractionQ99IB8:- (xeno); NbExp=4; IntAct=EBI-8852196, EBI-6901449;
Sequence CautionSequence=AAD40380.1; Type=Frameshift; Positions=2; Evidence={ECO:0000305};
SimilarityBelongs to the SPCS1 family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
SubunitComponent of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3. {ECO:0000250}.
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