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MGP004997

Record overview

MGPD IDMGP004997
Gene ID29108
SpeciesHomo sapiens (Human)
Gene NamePYD and CARD domain containing
Gene Symbol PYCARD
SynonymsASC; TMS; TMS1; CARD5; TMS-1;
Alternate namesapoptosis-associated speck-like protein containing a CARD; caspase recruitment domain-containing protein 5; target of methylation-induced silencing 1;
Chromosome16
Map Location16p11.2
SummaryThis gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PYCARD

Proteins

apoptosis-associated speck-like protein containing a CARD isoform a
Refseq ID:NP_037390
Protein GI:10835256
UniProt ID:Q9ULZ3
mRNA ID:NM_013258
Length:195
RefSeq Status:
MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGI
QAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS
 
apoptosis-associated speck-like protein containing a CARD isoform b
Refseq ID:NP_660183
Protein GI:22035620
UniProt ID:Q9ULZ3
mRNA ID:NM_145182
Length:176
RefSeq Status:
MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGLHFIDQHR
AALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS
 
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