MGP Database

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MGP004997

Ontology/Pathway Information

Entrez Gene ID29108
Gene NamePYD and CARD domain containing
Gene Symbol PYCARD
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0097169 IDA:UniProtKBCAIM2 inflammasome complex
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005783 IEA:UniProtKB-SubCellCendoplasmic reticulum
GO:0008385 TAS:HGNCCIkappaB kinase complex
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0072558 IDA:UniProtKBCNLRP1 inflammasome complex
GO:0072559 IDA:UniProtKBCNLRP3 inflammasome complex
GO:0005730 IDA:HPACnucleolus
GO:0005634 ISS:UniProtKBCnucleus
GO:0008656 NAS:UniProtKBFcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0042803 IDA:HGNCFprotein homodimerization activity
GO:0032090 IPI:HGNCFPyrin domain binding
GO:0006919 NAS:UniProtKBPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002218 IDA:UniProtKBPactivation of innate immune response
GO:0006915 TAS:ProtIncPapoptotic process
GO:0071347 IDA:UniProtKBPcellular response to interleukin-1
GO:0071222 IDA:UniProtKBPcellular response to lipopolysaccharide
GO:0071356 IDA:UniProtKBPcellular response to tumor necrosis factor
GO:0050829 IMP:UniProtKBPdefense response to Gram-negative bacterium
GO:0051607 IDA:UniProtKBPdefense response to virus
GO:0006954 IEA:UniProtKB-KWPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0072332 IMP:UniProtKBPintrinsic apoptotic signaling pathway by p53 class mediator
GO:0042771 IMP:UniProtKBPintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0044351 ISS:UniProtKBPmacropinocytosis
GO:0001773 IMP:UniProtKBPmyeloid dendritic cell activation
GO:0002277 ISS:UniProtKBPmyeloid dendritic cell activation involved in immune response
GO:0043124 IDA:UniProtKBPnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032688 IMP:UniProtKBPnegative regulation of interferon-beta production
GO:0032088 IMP:UniProtKBPnegative regulation of NF-kappaB transcription factor activity
GO:0071901 IDA:UniProtKBPnegative regulation of protein serine/threonine kinase activity
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0030838 ISS:UniProtKBPpositive regulation of actin filament polymerization
GO:0042104 ISS:UniProtKBPpositive regulation of activated T cell proliferation
GO:0002821 IMP:UniProtKBPpositive regulation of adaptive immune response
GO:0002588 ISS:UniProtKBPpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0090197 IMP:UniProtKBPpositive regulation of chemokine secretion
GO:2001056 IDA:UniProtKBPpositive regulation of cysteine-type endopeptidase activity
GO:0043280 IDA:HGNCPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070374 IMP:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:2001238 IDA:UniProtKBPpositive regulation of extrinsic apoptotic signaling pathway
GO:0032729 ISS:UniProtKBPpositive regulation of interferon-gamma production
GO:2001181 IMP:UniProtKBPpositive regulation of interleukin-10 secretion
GO:0050718 IDA:HGNCPpositive regulation of interleukin-1 beta secretion
GO:0032755 ISS:UniProtKBPpositive regulation of interleukin-6 production
GO:2000778 IMP:UniProtKBPpositive regulation of interleukin-6 secretion
GO:2000484 IMP:UniProtKBPpositive regulation of interleukin-8 secretion
GO:0046330 IMP:UniProtKBPpositive regulation of JNK cascade
GO:0051092 IDA:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0050766 ISS:UniProtKBPpositive regulation of phagocytosis
GO:0090200 IDA:UniProtKBPpositive regulation of release of cytochrome c from mitochondria
GO:0051091 IDA:UniProtKBPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0050870 IMP:UniProtKBPpositive regulation of T cell activation
GO:2000406 ISS:UniProtKBPpositive regulation of T cell migration
GO:0032760 IMP:UniProtKBPpositive regulation of tumor necrosis factor production
GO:2001242 IDA:UniProtKBPregulation of intrinsic apoptotic signaling pathway
GO:0031647 ISS:UniProtKBPregulation of protein stability
GO:0010803 IMP:UniProtKBPregulation of tumor necrosis factor-mediated signaling pathway
GO:0007165 NAS:UniProtKBPsignal transduction
GO:0033209 IDA:HGNCPtumor necrosis factor-mediated signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6900Immune System
REACT_75900Inflammasomes
REACT_6802Innate Immune System
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75777The AIM2 inflammasome
REACT_75808The NLRP3 inflammasome
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