MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP005046

UniProt Annotations

Entry Information
Gene NameKv channel interacting protein 2
Protein EntryKCIP2_HUMAN
UniProt IDQ9NS61
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=9; Name=1; Synonyms=KChIP2a, KChIP2b, KCHIP2.4, KCHIP2L; IsoId=Q9NS61-1; Sequence=Displayed; Name=2; Synonyms=3, KChIP2.1, KChIP2b; IsoId=Q9NS61-2; Sequence=VSP_015052; Name=3; Synonyms=2, KChIP2.2, KChIP2c, KCHIP2S; IsoId=Q9NS61-3; Sequence=VSP_015051; Name=4; IsoId=Q9NS61-4; Sequence=VSP_015050; Name=5; IsoId=Q9NS61-5; Sequence=VSP_015051, VSP_015056; Name=6; Synonyms=KCHIP4.2; IsoId=Q9NS61-6; Sequence=VSP_015053; Name=7; IsoId=Q9NS61-7; Sequence=VSP_015051, VSP_015055; Name=8; Synonyms=KCHIP2.6; IsoId=Q9NS61-8; Sequence=VSP_015049, VSP_015054; Name=9; Synonyms=KCHIP2.5; IsoId=Q9NS61-9; Sequence=VSP_015051, VSP_015057, VSP_015058;
FunctionRegulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Essential for the expression of I(To) currents in the heart and is also involved in controlling KCND2/Kv4.2-mediated I(To) currents in the heart (By similarity). Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium- dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. {ECO:0000250|UniProtKB:Q9JJ69, ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11287421, ECO:0000269|PubMed:11684073, ECO:0000269|PubMed:12297301, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:14623880}.
InteractionQ9NZV8:KCND2; NbExp=3; IntAct=EBI-1052975, EBI-1646745; Q9NZI2:KCNIP1; NbExp=4; IntAct=EBI-1053010, EBI-2120635;
PtmPalmitoylated. Palmitoylation enhances association with the plasma membrane. {ECO:0000250|UniProtKB:Q9JM59}.
SimilarityBelongs to the recoverin family. {ECO:0000305}.
SimilarityContains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular LocationIsoform 1: Cell membrane {ECO:0000250|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}.
Subcellular LocationIsoform 2: Cell membrane {ECO:0000250|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}.
Subcellular LocationIsoform 6: Cell membrane {ECO:0000250|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}.
SubunitComponent of heteromultimeric potassium channels. The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with KCND2. Isoform 1 and isoform 3 interact with KCND3 isoform 1. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. At least isoform 2 and isoform 3 can self-associate to form homodimers and homotetramers. Isoform 3 interacts with KCNIP1 in a calcium-dependent manner. {ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11287421, ECO:0000269|PubMed:12297301, ECO:0000269|PubMed:15356203, ECO:0000269|PubMed:15358149}.
Tissue SpecificityExpressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart. {ECO:0000269|PubMed:11263977, ECO:0000269|PubMed:11684073, ECO:0000269|PubMed:15356203}.
  logo