MGP Database

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MGP005051

UniProt Annotations

Entry Information
Gene Namephosphoinositide-3-kinase, regulatory subunit 4
Protein EntryPI3R4_HUMAN
UniProt IDQ99570
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:8999962};
FunctionRegulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway.
PtmMyristoylated. {ECO:0000269|PubMed:8999962}.
PtmProbably autophosphorylated. {ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:19369195, ECO:0000269|PubMed:8999962}.
SimilarityBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SimilarityContains 3 HEAT repeats. {ECO:0000255|PROSITE- ProRule:PRU00103}.
SimilarityContains 7 WD repeats. {ECO:0000255|PROSITE- ProRule:PRU00221}.
Subcellular LocationLate endosome {ECO:0000269|PubMed:14617358}. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}.
SubunitHeterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with the phosphatidylinositol 3-kinase type 3 (PIK3C3). Forms a complex with BECN1, PIK3C3 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed by PIK3C3 and PIK3CB (By similarity). Interacts with RAB7A in the presence of PIK3C3/VPS34. {ECO:0000250, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:8999962}.
Tissue SpecificityUbiquitously expressed. {ECO:0000269|PubMed:8999962}.
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