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MGP005063

Record overview

MGPD IDMGP005063
Gene ID50515
SpeciesHomo sapiens (Human)
Gene Namecarbohydrate (chondroitin 4) sulfotransferase 11
Gene Symbol CHST11
SynonymsC4ST; C4ST1; C4ST-1; HSA269537;
Alternate namescarbohydrate sulfotransferase 11; C4S-1; IgH/CHST11 fusion; chondroitin 4-O-sulfotransferase 1;
Chromosome12
Map Location12q
EC Number2.8.2.5
SummaryThe protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
OrthologsView orthologs and multiple alignments for CHST11

Proteins

carbohydrate sulfotransferase 11 isoform 1
Refseq ID:NP_060883
Protein GI:8923758
UniProt ID:Q9NPF2
mRNA ID:NM_018413
Length:352
RefSeq Status:
MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSMLHPVMRRNPFGVDICCRKGSRSPLQELYNPIQLELSNTAVLHQMRRDQVTDTCRANSATSRKRR
VLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKF
TQKYNISFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLK
FPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE
 
carbohydrate sulfotransferase 11 isoform 2
Refseq ID:NP_001167453
Protein GI:291219907
UniProt ID:Q9NPF2
mRNA ID:NM_001173982
Length:347
RefSeq Status:
MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQIMRRNPFGVDICCRKGSRSPLQELYNPIQLELSNTAVLHQMRRDQVTDTCRANSATSRKRRVLTPN
DLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYN
ISFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLKFPTYA
KSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE
 
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