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MGP005070

UniProt Annotations

Entry Information
Gene NameRho guanine nucleotide exchange factor (GEF) 3
Protein EntryARHG3_HUMAN
UniProt IDQ9NR81
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9NR81-1; Sequence=Displayed; Name=2; IsoId=Q9NR81-2; Sequence=VSP_011612; Note=No experimental confirmation available.; Name=3; IsoId=Q9NR81-3; Sequence=VSP_027205; Note=No experimental confirmation available.; Name=4; IsoId=Q9NR81-4; Sequence=VSP_027204, VSP_027206; Note=No experimental confirmation available.;
FunctionActs as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. {ECO:0000269|PubMed:12221096}.
Sequence CautionSequence=AAH68513.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14891.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92898.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityContains 1 DH (DBL-homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00062}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitInteracts with RHOA and RHOB.
Tissue SpecificityWidely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney. {ECO:0000269|PubMed:10873612, ECO:0000269|PubMed:12221096}.
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