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MGP005104

Record overview

MGPD IDMGP005104
Gene ID51053
SpeciesHomo sapiens (Human)
Gene Namegeminin, DNA replication inhibitor
Gene Symbol GMNN
SynonymsGem;
Alternate namesgeminin;
Chromosome6
Map Location6p22.3
SummaryThis gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]
OrthologsView orthologs and multiple alignments for GMNN

Proteins

geminin
Refseq ID:NP_001238918
Protein GI:354681980
UniProt ID:O75496
mRNA ID:NM_001251989
Length:209
RefSeq Status:
MNPSMKQKQEEIKENIKNSSVPRRTLKMIQPSASGSLVGRENELSAGLSKRKHRNDHLTSTTSSPGVIVPESSENKNLGGVTQESFDLMIKENPSSQYWK
EVAEKRRKALYEALKENEKLHKEIEQKDNEIARLKKENKELAEVAEHVQYMAELIERLNGEPLDNFESLDNQEFDSEEETVEDSLVEDSEIGTCAEGTVS
SSTDAKPCI
 
geminin
Refseq ID:NP_056979
Protein GI:7705682
UniProt ID:O75496
mRNA ID:NM_015895
Length:209
RefSeq Status:
Protein sequence is identical to GI:354681980 (mRNA isoform)
 
geminin
Refseq ID:NP_001238920
Protein GI:354681985
UniProt ID:O75496
mRNA ID:NM_001251991
Length:209
RefSeq Status:
Protein sequence is identical to GI:354681980 (mRNA isoform)
 
geminin
Refseq ID:NP_001238919
Protein GI:354681983
UniProt ID:O75496
mRNA ID:NM_001251990
Length:209
RefSeq Status:
Protein sequence is identical to GI:354681980 (mRNA isoform)
 
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