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MGP005133

UniProt Annotations

Entry Information
Gene Namevacuolar protein sorting 28 homolog (S. cerevisiae)
Protein EntryVPS28_HUMAN
UniProt IDQ9UK41
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UK41-1; Sequence=Displayed; Name=2; IsoId=Q9UK41-2; Sequence=VSP_042028; Note=No experimental confirmation available.;
FunctionComponent of the ESCRT-I complex, a regulator of vesicular trafficking process. {ECO:0000269|PubMed:11916981}.
InteractionQ99816:TSG101; NbExp=3; IntAct=EBI-727424, EBI-346882;
SimilarityBelongs to the VPS28 family. {ECO:0000255|PROSITE- ProRule:PRU00642, ECO:0000255|PROSITE-ProRule:PRU00645}.
SimilarityContains 1 VPS28 C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00642}.
SimilarityContains 1 VPS28 N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00645}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:11916981}. Late endosome membrane {ECO:0000269|PubMed:11916981}; Peripheral membrane protein {ECO:0000269|PubMed:11916981}.
SubunitComponent of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS37B, VPS37C, MVB12A and MVB12B. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoechiometry. Interacts WITH VPS36; the interaction mediates the association with the ESCRT-II complex. Interacts with SNF8 and VPS25. Interacts with CEP55. {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:15218037, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18005716, ECO:0000269|PubMed:18539118, ECO:0000269|PubMed:21757351}.
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