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MGP005189

Record overview

MGPD IDMGP005189
Gene ID51447
SpeciesHomo sapiens (Human)
Gene Nameinositol hexakisphosphate kinase 2
Gene Symbol IP6K2
SynonymsPIUS; IHPK2;
Alternate namesinositol hexakisphosphate kinase 2; ATP:1D-myo-inositol-hexakisphosphate phosphotransferase; inositol hexaphosphate kinase 2; insp6 kinase 2; pi uptake stimulator;
Chromosome3
Map Location3p21.31
EC Number2.7.4.21
SummaryThis gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for IP6K2

Proteins

inositol hexakisphosphate kinase 2 isoform a
Refseq ID:NP_001005909
Protein GI:55769520
UniProt ID:Q9UHH9
mRNA ID:NM_001005909
Length:426
RefSeq Status:
MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRKFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVD
NSDCEPKSKLLRWTTNKKHHVLETEKTPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYTVEKKGNISSQLKHYNPWSMKCHQQQLQRMKENAKHRNQ
YKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLR
RELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKERPEVVLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDTVVHE
GQDAGYIFGLQSLIDIVTEISEESGE
 
inositol hexakisphosphate kinase 2 isoform a
Refseq ID:NP_057375
Protein GI:56237025
UniProt ID:Q9UHH9
mRNA ID:NM_016291
Length:426
RefSeq Status:
Protein sequence is identical to GI:55769520 (mRNA isoform)
 
inositol hexakisphosphate kinase 2 isoform b
Refseq ID:NP_001005910
Protein GI:55769522
UniProt ID:Q9UHH9
mRNA ID:NM_001005910
Length:97
RefSeq Status:
MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRKFTPQYKGQSQRPLVSWPSLPHFFPWSFPLWPQGSVA
 
inositol hexakisphosphate kinase 2 isoform b
Refseq ID:NP_001005911
Protein GI:55769524
UniProt ID:Q9UHH9
mRNA ID:NM_001005911
Length:97
RefSeq Status:
Protein sequence is identical to GI:55769522 (mRNA isoform)
 
inositol hexakisphosphate kinase 2 isoform c
Refseq ID:NP_001139650
Protein GI:226051954
UniProt ID:Q9UHH9
mRNA ID:NM_001146178
Length:87
RefSeq Status:
MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRKFTPQYKGDISSHQHGGVFVGEWGSLL
 
inositol hexakisphosphate kinase 2 isoform c
Refseq ID:NP_001139651
Protein GI:226051970
UniProt ID:Q9UHH9
mRNA ID:NM_001146179
Length:87
RefSeq Status:
Protein sequence is identical to GI:226051954 (mRNA isoform)
 
inositol hexakisphosphate kinase 2 isoform d
Refseq ID:NP_001177245
Protein GI:298286521
UniProt ID:Q9UHH9
mRNA ID:NM_001190316
Length:185
RefSeq Status:
MSLNLPEASLLSRASWPEQAKEPRREGHTDKQQTEDVLAAGLRCLPHLPAICARRMSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLV
PREHQFYETLPAEMRKFTPQYKGKSQLLEGLPHWRGDVRDRGHGRPWQPSLEPSLPPTLCFPSLSSFSSSWPSAQHLTPSVFNPW
 
inositol hexakisphosphate kinase 2 isoform e
Refseq ID:NP_001177246
Protein GI:298286523
UniProt ID:Q9UHH9
mRNA ID:NM_001190317
Length:188
RefSeq Status:
MNLCQSPFQEGCQSLLASWPEQAKEPRREGHTDKQQTEDVLAAGLRCLPHLPAICARRMSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCK
PLVPREHQFYETLPAEMRKFTPQYKGKSQLLEGLPHWRGDVRDRGHGRPWQPSLEPSLPPTLCFPSLSSFSSSWPSAQHLTPSVFNPW
 
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