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MGP005195

Record overview

MGPD IDMGP005195
Gene ID51478
SpeciesHomo sapiens (Human)
Gene Namehydroxysteroid (17-beta) dehydrogenase 7
Gene Symbol HSD17B7
SynonymsPRAP; SDR37C1;
Alternate names3-keto-steroid reductase; 17 beta-hydroxysteroid dehydrogenase type VII; 17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7; 17beta hydroxysteroid dehydrogenase; estradiol 17-beta-dehydrogenase 7; short chain dehydrogenase/reductase family 37C, member 1;
Chromosome1
Map Location1q23
EC Number1.1.1.270
SummaryHSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]
OrthologsView orthologs and multiple alignments for HSD17B7

Proteins

3-keto-steroid reductase isoform 1
Refseq ID:NP_057455
Protein GI:7705421
UniProt ID:P56937
mRNA ID:NM_016371
Length:341
RefSeq Status:
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLN
IKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYAT
DLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQ
KMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
 
3-keto-steroid reductase isoform 2
Refseq ID:NP_001291441
Protein GI:751368102
UniProt ID:
mRNA ID:NM_001304512
Length:155
RefSeq Status:
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLN
IKALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILVKKLWA
 
3-keto-steroid reductase isoform 3
Refseq ID:NP_001291442
Protein GI:751368104
UniProt ID:
mRNA ID:NM_001304513
Length:111
RefSeq Status:
MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLN
IKALFFGLFSS
 
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