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MGP005195

UniProt Annotations

Entry Information
Gene Namehydroxysteroid (17-beta) dehydrogenase 7
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P56937-1; Sequence=Displayed; Name=2; IsoId=P56937-2; Sequence=VSP_006029; Name=3; IsoId=P56937-3; Sequence=VSP_012766;
Catalytic Activity17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Catalytic ActivityA 3-beta-hydroxysteroid + NADP(+) = a 3- oxosteroid + NADPH.
FunctionResponsible for the reduction of the keto group on the C-3 of sterols. {ECO:0000269|PubMed:12829805}.
PathwaySteroid biosynthesis; estrogen biosynthesis.
PathwaySteroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.
PtmPhosphorylated.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. {ECO:0000305}.
Subcellular LocationCell membrane; Single-pass membrane protein.
Tissue SpecificityHighly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells.
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