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MGP005215

Record overview

MGPD IDMGP005215
Gene ID51611
SpeciesHomo sapiens (Human)
Gene Namediphthamide biosynthesis 5
Gene Symbol DPH5
SynonymsAD-018; CGI-30; NPD015; HSPC143;
Alternate namesdiphthine synthase; DPH5 homolog; diphthamide biosynthesis methyltransferase; protein x 0011;
Chromosome1
Map Location1p21.2
EC Number2.1.1.98
SummaryThis gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DPH5

Proteins

diphthine synthase isoform a
Refseq ID:NP_057042
Protein GI:117190262
UniProt ID:Q9H2P9
mRNA ID:NM_015958
Length:285
RefSeq Status:
MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREEVEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATK
LGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEI
VQNQRIRGEEPAVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL
 
diphthine synthase isoform a
Refseq ID:NP_001070862
Protein GI:117190326
UniProt ID:Q9H2P9
mRNA ID:NM_001077394
Length:285
RefSeq Status:
Protein sequence is identical to GI:117190262 (mRNA isoform)
 
diphthine synthase isoform b
Refseq ID:NP_001070863
Protein GI:117190324
UniProt ID:Q9H2P9
mRNA ID:NM_001077395
Length:284
RefSeq Status:
MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLVVADREEVEQEADNILKDADISDVAFLVVGDPFGATTHSDLVLRATK
LGIPYRVIHNASIMNAVGCCGLQLYKFGETVSIVFWTDTWRPESFFDKVKKNRQNGMHTLCLLDIKVKEQSLENLIKGRKIYEPPRYMSVNQAAQQLLEI
VQNQRIRGEEPVTEETLCVGLARVGADDQKIAAGTLRQMCTVDLGEPLHSLIITGGSIHPMEMEMLSLFSIPENSSESQSINGL
 
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