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MGP005215

UniProt Annotations

Entry Information
Gene Namediphthamide biosynthesis 5
Protein EntryDPH5_HUMAN
UniProt IDQ9H2P9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q9H2P9-1; Sequence=Displayed; Name=2; IsoId=Q9H2P9-2; Sequence=VSP_008508; Note=No experimental confirmation available.; Name=3; IsoId=Q9H2P9-3; Sequence=VSP_008509; Note=No experimental confirmation available.; Name=4; IsoId=Q9H2P9-4; Sequence=VSP_008510; Note=No experimental confirmation available.; Name=5; IsoId=Q9H2P9-5; Sequence=VSP_008511; Note=No experimental confirmation available.; Name=6; IsoId=Q9H2P9-6; Sequence=VSP_043444; Note=No experimental confirmation available.;
Catalytic Activity3 S-adenosyl-L-methionine + 2-(3-carboxy-3- aminopropyl)-L-histidine-[translation elongation factor 2] = 3 S- adenosyl-L-homocysteine + 2-(3-carboxy-3- (trimethylammonio)propyl)-L-histidine-[translation elongation factor 2].
FunctionS-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EEF2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. {ECO:0000269|PubMed:23486472}.
PathwayProtein modification; peptidyl-diphthamide biosynthesis.
SimilarityBelongs to the diphthine synthase family. {ECO:0000305}.
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