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MGP005216

UniProt Annotations

Entry Information
Gene NameTAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
Protein EntryTAF9B_HUMAN
UniProt IDQ9HBM6
SpeciesHuman
Comments
Comment typeDescription
FunctionEssential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. {ECO:0000269|PubMed:15899866}.
SimilarityBelongs to the TAF9 family. {ECO:0000255}.
Subcellular LocationNucleus {ECO:0000250}.
SubunitBinds TAF5 and TAF6. Component of TFIID and the TATA- binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription. {ECO:0000269|PubMed:15899866}.
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