MGP Database

MGP005247

Record overview

MGPD IDMGP005247
Gene ID51752
SpeciesHomo sapiens (Human)
Gene Nameendoplasmic reticulum aminopeptidase 1
Gene Symbol ERAP1
SynonymsALAP; A-LAP; ARTS1; ERAAP; APPILS; ARTS-1; ERAAP1; PILSAP; PILS-AP;
Alternate namesendoplasmic reticulum aminopeptidase 1; adipocyte-derived leucine aminopeptidase; aminopeptidase PILS; aminopeptidase regulator of TNFR1 shedding; endoplasmic reticulum aminopeptidase 1 delta-Exon-11 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-13 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-14 isoform; endoplasmic reticulum aminopeptidase 1 delta-Exon-15 isoform; endoplasmic reticulum aminopeptidase associated with antigen processing; puromycin-insensitive leucyl-specific aminopeptidase; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator;
Chromosome5
Map Location5q15
EC Number3.4.11.-
SummaryThe protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
OrthologsView orthologs and multiple alignments for ERAP1

Proteins

endoplasmic reticulum aminopeptidase 1 isoform a precursor
Refseq ID:NP_057526
Protein GI:94818901
UniProt ID:Q9NZ08
mRNA ID:NM_016442
Length:948
RefSeq Status:
MVFLPLKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHL
QISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFK
ASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIP
YPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYF
FGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSR
SQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKF
NVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFK
AFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQ
IEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKE
NGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKLEHDPEADATG
 
sig_peptide: 1..32
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3557
peptide sequence: 
MVFLPLKWSLATMSFLLSSLLALLTVSTPSWC

sig_peptide: 1..32
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3557
peptide sequence: 
MVFLPLKWSLATMSFLLSSLLALLTVSTPSWC
 
endoplasmic reticulum aminopeptidase 1 isoform b precursor
Refseq ID:NP_001185470
Protein GI:309747091
UniProt ID:Q9NZ08
mRNA ID:NM_001198541
Length:941
RefSeq Status:
MVFLPLKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHL
QISRATLRKGAGERLSEEPLQVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFK
ASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIP
YPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYF
FGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSR
SQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGRNVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKF
NVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFK
AFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQ
IEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKE
NGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKLERM
 
sig_peptide: 1..32
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3557
peptide sequence: 
MVFLPLKWSLATMSFLLSSLLALLTVSTPSWC
 
endoplasmic reticulum aminopeptidase 1 isoform b precursor
Refseq ID:NP_001035548
Protein GI:94818891
UniProt ID:Q9NZ08
mRNA ID:NM_001040458
Length:941
RefSeq Status:
Protein sequence is identical to GI:309747091 (mRNA isoform)
 
sig_peptide: 1..32
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3557
peptide sequence: 
MVFLPLKWSLATMSFLLSSLLALLTVSTPSWC

sig_peptide: 1..32
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3557
peptide sequence: 
MVFLPLKWSLATMSFLLSSLLALLTVSTPSWC

sig_peptide: 1..32
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3557
peptide sequence: 
MVFLPLKWSLATMSFLLSSLLALLTVSTPSWC
 
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