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MGP005248

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate-5-phosphatase K
Protein EntryINP5K_HUMAN
UniProt IDQ9BT40
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1 {ECO:0000269|PubMed:10753883}; IsoId=Q9BT40-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:10753883}; IsoId=Q9BT40-2; Sequence=VSP_050612;
Catalytic ActivityD-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate. {ECO:0000269|PubMed:10753883}.
FunctionInositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5- trisphosphate. May negatively regulate assembly of the actin cytoskeleton. {ECO:0000269|PubMed:10753883}.
InteractionQ8TBB1:LNX1; NbExp=3; IntAct=EBI-749162, EBI-739832;
SimilarityBelongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum {ECO:0000269|PubMed:12536145}. Note=Following stimulation with EGF, translocates to membrane ruffles.
Tissue SpecificityUbiquitously expressed with highest levels in skeletal muscle, heart and kidney. {ECO:0000269|PubMed:10753883}.
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