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MGP005250

Record overview

MGPD IDMGP005250
Gene ID51765
SpeciesHomo sapiens (Human)
Gene Nameserine/threonine protein kinase 26
Gene Symbol STK26
SynonymsMASK; MST4;
Alternate namesserine/threonine-protein kinase 26; Mst3 and SOK1-related kinase; STE20-like kinase 4; STE20-like kinase MST4; mammalian Ste20-like protein kinase 4; mammalian sterile 20-like 4; serine/threonine protein kinase MST4; serine/threonine-protein kinase MASK;
ChromosomeX
Map LocationXq26.2
EC Number2.7.11.1
SummaryThe product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for STK26

Proteins

serine/threonine-protein kinase 26 isoform 1
Refseq ID:NP_057626
Protein GI:15011880
UniProt ID:Q9P289
mRNA ID:NM_016542
Length:416
RefSeq Status:
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIME
YLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKA
DIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS
DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMV
KKLIEKFQKCSADESP
 
serine/threonine-protein kinase 26 isoform 2
Refseq ID:NP_001035918
Protein GI:109633028
UniProt ID:Q9P289
mRNA ID:NM_001042453
Length:339
RefSeq Status:
MAHSPVAVQVPGMQGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRN
TFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKN
SKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQA
IEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
 
serine/threonine-protein kinase 26 isoform 3
Refseq ID:NP_001035917
Protein GI:109633026
UniProt ID:Q9P289
mRNA ID:NM_001042452
Length:354
RefSeq Status:
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIME
YLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKR
PTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFA
ELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
 
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