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MGP005250

UniProt Annotations

Entry Information
Gene Nameserine/threonine protein kinase 26
Protein EntrySTK26_HUMAN
UniProt IDQ9P289
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9P289-1; Sequence=Displayed; Name=2; IsoId=Q9P289-2; Sequence=VSP_041469; Name=3; Synonyms=MST4a; IsoId=Q9P289-3; Sequence=VSP_041470;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:11641781}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Enzyme RegulationInteraction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C- terminal cleavage. {ECO:0000269|PubMed:15037601}.
FunctionMediator of cell growth. Modulates apoptosis. {ECO:0000269|PubMed:11641781, ECO:0000269|PubMed:17360971}.
InteractionSelf; NbExp=4; IntAct=EBI-618239, EBI-618239; Q9Y376:CAB39; NbExp=6; IntAct=EBI-618239, EBI-306905; Q9P2B4:CTTNBP2NL; NbExp=4; IntAct=EBI-618239, EBI-1774273; Q5VSL9:STRIP1; NbExp=2; IntAct=EBI-618239, EBI-1773588;
SimilarityBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. {ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationCytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Golgi apparatus.
SubunitHomodimer. Interacts with PDCD10 and GOLGA2. Interacts with CTTNBP2NL. {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:19370760, ECO:0000269|PubMed:20332113, ECO:0000269|PubMed:20730082}.
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