MGP Database

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MGP005256

Ontology/Pathway Information

Entrez Gene ID53354
Gene Namepantothenate kinase 1
Gene Symbol PANK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0071944 IEA:EnsemblCcell periphery
GO:0030118 IEA:EnsemblCclathrin coat
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IEA:EnsemblCnucleus
GO:0055037 IEA:EnsemblCrecycling endosome
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004594 IEA:UniProtKB-ECFpantothenate kinase activity
GO:0015937 IEA:UniProtKB-UniPathwayPcoenzyme A biosynthetic process
GO:0009108 TAS:ReactomePcoenzyme biosynthetic process
GO:0015939 TAS:ReactomePpantothenate metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006766 TAS:ReactomePvitamin metabolic process
GO:0006767 TAS:ReactomePwater-soluble vitamin metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_11218Coenzyme A biosynthesis
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_111217Metabolism
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_11172Vitamin B5 (pantothenate) metabolism
SMP Pathway Links
SMP IDDescription
SMP00572Fanconi-bickel syndrome
SMP00562Fructose-1,6-diphosphatase deficiency
SMP00128Gluconeogenesis
SMP00581Glycogenosis, Type IA. Von gierke disease
SMP00573Glycogenosis, Type IB
SMP00574Glycogenosis, Type IC
SMP00531Glycogenosis, Type VII. Tarui disease
SMP00374Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease
SMP00040Glycolysis
SMP00027Pantothenate and CoA Biosynthesis
SMP00560Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1)
SMP00563Triosephosphate isomerase
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