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MGP005256

UniProt Annotations

Entry Information
Gene Namepantothenate kinase 1
Protein EntryPANK1_HUMAN
UniProt IDQ8TE04
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=PanK1-alpha, PANK1a; IsoId=Q8TE04-1; Sequence=Displayed; Name=2; Synonyms=PANK1a, PanK1-beta; IsoId=Q8TE04-2; Sequence=VSP_004520; Name=3; Synonyms=PANK1b; IsoId=Q8TE04-3; Sequence=VSP_004520, VSP_004521; Name=4; Synonyms=PanK1-gamma; IsoId=Q8TE04-4; Sequence=VSP_012823, VSP_012824;
Catalytic ActivityATP + (R)-pantothenate = ADP + (R)-4'- phosphopantothenate.
DomainThe N-terminal extension, present in isoform 1 may be the regulatory domain.
Enzyme RegulationRegulated by feedback inhibition by CoA and its thioesters. Strongly inhibited by acetyl-CoA and by manyl-CoA and also inhibited by high concentration of non-esterified CoA (CoASH) (By similarity). {ECO:0000250}.
FunctionPlays a role in the physiological regulation of the intracellular CoA concentration. {ECO:0000250}.
InductionIsoform 1 is induced by bezafibrate, a hypolipidemic drug which acts as an agonist of peroxisome proliferator activator receptor alpha (PPARA), while isoform 2 levels decrease slightly. {ECO:0000269|PubMed:14523052}.
PathwayCofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Sequence CautionSequence=AAH26296.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the type II pantothenate kinase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:14523052}.
SubunitHomodimer. {ECO:0000269|PubMed:17631502}.
Tissue SpecificityIsoform 1 is expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. Isoform 2 is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle. {ECO:0000269|PubMed:14523052}.
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