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MGP005282

Record overview

MGPD IDMGP005282
Gene ID54363
SpeciesHomo sapiens (Human)
Gene Namehydroxyacid oxidase (glycolate oxidase) 1
Gene Symbol HAO1
SynonymsGOX; GOX1; HAOX1;
Alternate nameshydroxyacid oxidase 1; (S)-2-hydroxy-acid oxidase; glycolate oxidase;
Chromosome20
Map Location20p12
EC Number1.1.3.15
SummaryThis gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for HAO1

Proteins

hydroxyacid oxidase 1
Refseq ID:NP_060015
Protein GI:11068137
UniProt ID:Q9UJM8
mRNA ID:NM_017545
Length:370
RefSeq Status:
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQS
LGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFG
DDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDV
LKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
 
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