MGP Database

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MGP005282

UniProt Annotations

Entry Information
Gene Namehydroxyacid oxidase (glycolate oxidase) 1
Protein EntryHAOX1_HUMAN
UniProt IDQ9UJM8
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=141 uM for glycolate {ECO:0000269|PubMed:18215067}; KM=40 uM for 2-hydroxy octanoate {ECO:0000269|PubMed:18215067}; KM=2200 uM for glyoxylate {ECO:0000269|PubMed:18215067};
Catalytic Activity(S)-2-hydroxy acid + O(2) = 2-oxo acid + H(2)O(2). {ECO:0000269|PubMed:18215067}.
CofactorName=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000255|PROSITE-ProRule:PRU00683, ECO:0000269|PubMed:18215067};
FunctionHas 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2- hydroxy octanoate. {ECO:0000269|PubMed:18215067}.
PathwayOrganic acid metabolism; glycolate degradation; 3- phospho-D-glycerate from glycolate: step 1/4.
SimilarityBelongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. {ECO:0000255|PROSITE-ProRule:PRU00683}.
SimilarityContains 1 FMN hydroxy acid dehydrogenase domain. {ECO:0000255|PROSITE-ProRule:PRU00683}.
Subcellular LocationPeroxisome.
Tissue SpecificityLiver.
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