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MGP005291

Record overview

MGPD IDMGP005291
Gene ID54490
SpeciesHomo sapiens (Human)
Gene NameUDP glucuronosyltransferase 2 family, polypeptide B28
Gene Symbol UGT2B28
Alternate namesUDP-glucuronosyltransferase 2B28; UDP glycosyltransferase 2 family, polypeptide B28; UDPGT 2B28;
Chromosome4
Map Location4q13.2
EC Number2.4.1.17
SummaryThis gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active. [provided by RefSeq, May 2011]
OrthologsView orthologs and multiple alignments for UGT2B28

Proteins

UDP-glucuronosyltransferase 2B28 isoform 1 precursor
Refseq ID:NP_444267
Protein GI:16596680
UniProt ID:Q9BY64
mRNA ID:NM_053039
Length:529
RefSeq Status:
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDI
QKDSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSK
LSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQP
DNIAHMKAKGAAVRLDFHTMSSTDLLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHSLDVIGFLLAC
VATVIFVVTKFCLFCFWKFARKGKKGKRD
 
sig_peptide: 1..24
calculated_mol_wt: 2587
peptide sequence: 
MALKWTSVLLLIHLGCYFSSGSCG

mat_peptide: 25..335
product: UDP-glucuronosyltransferase 2B28 isoform 2
calculated_mol_wt: 36174
peptide sequence: 
KVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFHDIFR
NFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWF
QMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVI
ATALAKIPQKI

sig_peptide: 1..24
inference: non-experimental evidence, no additional details recorded
note: Potential; propagated from UniProtKB/Swiss-Prot (Q9BY64.1)
calculated_mol_wt: 2587
peptide sequence: 
MALKWTSVLLLIHLGCYFSSGSCG

mat_peptide: 25..529
product: UDP-glucuronosyltransferase 2B28
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9BY64.1)
calculated_mol_wt: 58338
peptide sequence: 
KVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFHDIFR
NFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWF
QMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVI
ATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMSSTD
LLNALKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHSLDVIGFLLACVATVIFVVTKFCLFCFWKFARKGK
KGKRD
 
UDP-glucuronosyltransferase 2B28 isoform 2 precursor
Refseq ID:NP_001193933
Protein GI:333033811
UniProt ID:Q9BY64
mRNA ID:NM_001207004
Length:335
RefSeq Status:
MALKWTSVLLLIHLGCYFSSGSCGKVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDI
QKDSFWLYFSQEQEILWEFHDIFRNFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSK
LSDQMTFMERVKNMIYVLYFDFWFQMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG
ENGVVVFSLGSVISNMTAERANVIATALAKIPQKI
 
sig_peptide: 1..24
calculated_mol_wt: 2587
peptide sequence: 
MALKWTSVLLLIHLGCYFSSGSCG

mat_peptide: 25..335
product: UDP-glucuronosyltransferase 2B28 isoform 2
calculated_mol_wt: 36174
peptide sequence: 
KVLVWTGEYSHWMNMKTILKELVQRGHEVTVLASSASILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFHDIFR
NFCKDVVSNKKVMKKLQESRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLYFDFWF
QMCDMKKWDQFYSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMTAERANVI
ATALAKIPQKI
 
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