MGP Database

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MGP005291

UniProt Annotations

Entry Information
Gene NameUDP glucuronosyltransferase 2 family, polypeptide B28
Protein EntryUDB28_HUMAN
UniProt IDQ9BY64
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=I; IsoId=Q9BY64-1; Sequence=Displayed; Name=2; Synonyms=II; IsoId=Q9BY64-2; Sequence=VSP_006710, VSP_006711;
Catalytic ActivityUDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. {ECO:0000269|PubMed:11300766}.
FunctionUDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active. {ECO:0000269|PubMed:11300766}.
Sequence CautionSequence=AAK31809.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
SimilarityBelongs to the UDP-glycosyltransferase family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000269|PubMed:11300766}; Single-pass membrane protein {ECO:0000269|PubMed:11300766}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11300766}; Single-pass membrane protein {ECO:0000269|PubMed:11300766}.
Tissue SpecificityExpressed in the liver, breast and kidney. {ECO:0000269|PubMed:11300766}.
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