MGP Database

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MGP005304

Ontology/Pathway Information

Entrez Gene ID54567
Gene Namedelta-like 4 (Drosophila)
Gene Symbol DLL4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005509 IEA:InterProFcalcium ion binding
GO:0005112 TAS:ProtIncFNotch binding
GO:0001525 ISS:BHF-UCLPangiogenesis
GO:0008015 TAS:ProtIncPblood circulation
GO:0072554 IEA:EnsemblPblood vessel lumenization
GO:0001974 ISS:BHF-UCLPblood vessel remodeling
GO:0003209 ISS:BHF-UCLPcardiac atrium morphogenesis
GO:0003208 ISS:BHF-UCLPcardiac ventricle morphogenesis
GO:0044344 IDA:UniProtKBPcellular response to fibroblast growth factor stimulus
GO:0035924 IMP:UniProtKBPcellular response to vascular endothelial growth factor stimulus
GO:0035912 ISS:BHF-UCLPdorsal aorta morphogenesis
GO:1903588 IDA:UniProtKBPnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0090051 IDA:UniProtKBPnegative regulation of cell migration involved in sprouting angiogenesis
GO:0008285 IMP:UniProtKBPnegative regulation of cell proliferation
GO:0010596 IMP:UniProtKBPnegative regulation of endothelial cell migration
GO:0010629 IDA:UniProtKBPnegative regulation of gene expression
GO:0000122 ISS:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0007220 TAS:ReactomePNotch receptor processing
GO:0061314 ISS:BHF-UCLPNotch signaling involved in heart development
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0001569 ISS:BHF-UCLPpatterning of blood vessels
GO:0003344 ISS:BHF-UCLPpericardium morphogenesis
GO:0010628 IDA:UniProtKBPpositive regulation of gene expression
GO:2000179 ISS:UniProtKBPpositive regulation of neural precursor cell proliferation
GO:0061074 ISS:UniProtKBPregulation of neural retina development
GO:0050767 IEA:EnsemblPregulation of neurogenesis
GO:0007165 TAS:ProtIncPsignal transduction
GO:0060579 IMP:UniProtKBPventral spinal cord interneuron fate commitment
GO:0003222 ISS:BHF-UCLPventricular trabecula myocardium morphogenesis
GO:0007601 IEA:UniProtKB-KWPvisual perception
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118614Activated NOTCH1 Transmits Signal to the Nucleus
REACT_160089Constitutive Signaling by NOTCH1 HD Domain Mutants
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_160106Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_116125Disease
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_160205NOTCH2 Activation and Transmission of Signal to the Nucleus
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_118721Signaling by NOTCH2
REACT_118862Signaling by NOTCH3
REACT_118636Signaling by NOTCH4
REACT_111102Signal Transduction
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