MGP Database

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MGP005304

UniProt Annotations

Entry Information
Gene Namedelta-like 4 (Drosophila)
Protein EntryDLL4_HUMAN
UniProt IDQ9NR61
SpeciesHuman
Comments
Comment typeDescription
DomainThe Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.
FunctionInvolved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. {ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:20616313}.
PtmUbiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. {ECO:0000250}.
SimilarityContains 1 DSL domain. {ECO:0000255|PROSITE- ProRule:PRU00377}.
SimilarityContains 8 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
SubunitBinds to Notch-1 and Notch-4. {ECO:0000250}.
Tissue SpecificityExpressed in vascular endothelium.
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