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MGP005312

UniProt Annotations

Entry Information

Gene Name	UDP glucuronosyltransferase 1 family, polypeptide A9
Protein Entry	UD19_HUMAN
UniProt ID	O60656
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=i1; IsoId=O60656-1; Sequence=Displayed; Name=2; Synonyms=i2, UGT1A9s; IsoId=O60656-2; Sequence=VSP_053965;
Catalytic Activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. {ECO:0000269\|PubMed:18004212, ECO:0000269\|PubMed:20610558}.
Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269\|PubMed:19545173}.
Miscellaneous	The gene is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.
Sequence Caution	Sequence=AAB19791.2; Type=Frameshift; Positions=59, 82; Evidence={ECO:0000305};
Similarity	Belongs to the UDP-glycosyltransferase family. {ECO:0000305}.
Subcellular Location	Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Subunit	Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8 and UGT1A10. {ECO:0000269\|PubMed:20610558}.
Tissue Specificity	Liver. Isoform 1 and isoform 2 are expressed in liver, kidney, colon, esophagus and small intestine. {ECO:0000269\|PubMed:18004212}.