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MGP005313

Record overview

MGPD IDMGP005313
Gene ID54657
SpeciesHomo sapiens (Human)
Gene NameUDP glucuronosyltransferase 1 family, polypeptide A4
Gene Symbol UGT1A4
SynonymsUDPGT; UGT1D; UGT-1D; UGT1.4; HUG-BR2; UGT1-04; UDPGT 1-4;
Alternate namesUDP-glucuronosyltransferase 1-4; UDP glycosyltransferase 1 family, polypeptide A4; UDP-glucuronosyltransferase 1-D; UDP-glucuronosyltransferase 1A4; bilirubin UDP-glucuronosyltransferase isozyme 2; bilirubin-specific UDPGT isozyme 2;
Chromosome2
Map Location2q37
EC Number2.4.1.17
SummaryThis gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for UGT1A4

Proteins

UDP-glucuronosyltransferase 1-4 precursor
Refseq ID:NP_009051
Protein GI:6005930
UniProt ID:P22310
mRNA ID:NM_007120
Length:534
RefSeq Status:
MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSMREALRELHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGF
FETEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTT
NSDHMTFLQRVKNMLYPLALSYICHTFSAPYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGE
HGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMD
NAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVV
LTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
 
sig_peptide: 1..28
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3031
peptide sequence: 
MARGLQVPLPRLATGLLLLLSVQPWAES

mat_peptide: 29..534
product: UDP-glucuronosyltransferase 1-4
calculated_mol_wt: 57013
peptide sequence: 
GKVLVVPTDGSPWLSMREALRELHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRCC
VELLHNEALIRHLNATSFDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFS
APYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALG
KIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENAL
KAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKA
HKSKTH
 
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