MGP Database

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MGP005313

Ontology/Pathway Information

Entrez Gene ID54657
Gene NameUDP glucuronosyltransferase 1 family, polypeptide A4
Gene Symbol UGT1A4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0005789 IBA:GO_CentralCendoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0019899 IPI:BHF-UCLFenzyme binding
GO:0015020 IDA:UniProtKBFglucuronosyltransferase activity
GO:0046982 IDA:UniProtKBFprotein heterodimerization activity
GO:0042803 IDA:UniProtKBFprotein homodimerization activity
GO:0052695 IDA:UniProtKBPcellular glucuronidation
GO:0032870 IBA:GO_CentralPcellular response to hormone stimulus
GO:0009813 IBA:GO_CentralPflavonoid biosynthetic process
GO:0052696 IBA:GO_CentralPflavonoid glucuronidation
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0052697 IBA:GO_CentralPxenobiotic glucuronidation
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_268587Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
REACT_268321Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
REACT_268129Defective GGT1 causes Glutathionuria (GLUTH)
REACT_267887Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
REACT_268063Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
REACT_268256Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
REACT_267818Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
REACT_268027Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
REACT_268058Defective UGT1A1 causes hyperbilirubinemia
REACT_268618Defective UGT1A4 causes hyperbilirubinemia
REACT_116125Disease
REACT_6784Glucuronidation
REACT_22297Heme degradation
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_9431Metabolism of porphyrins
REACT_6959Phase II conjugation
SMP Pathway Links
SMP IDDescription
SMP00431Nicotine Action Pathway
SMP00628Nicotine Metabolism Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00471Tamoxifen Action Pathway
SMP00606Tamoxifen Metabolism Pathway
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