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MGP005356

UniProt Annotations

Entry Information
Gene Namenicotinamide riboside kinase 1
Protein EntryNRK1_HUMAN
UniProt IDQ9NWW6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NWW6-1; Sequence=Displayed; Name=2; IsoId=Q9NWW6-2; Sequence=VSP_012676; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.088 mM for nicotinamide riboside (with ATP as cosubstrate) {ECO:0000269|PubMed:17914902, ECO:0000269|PubMed:8809081}; KM=0.068 mM for nicotinamide riboside (with GTP as cosubstrate) {ECO:0000269|PubMed:17914902, ECO:0000269|PubMed:8809081}; KM=0.27 mM for tiazofurin (with ATP as cosubstrate) {ECO:0000269|PubMed:17914902, ECO:0000269|PubMed:8809081}; KM=0.051 mM for nicotinic acid riboside (with ATP as cosubstrate) {ECO:0000269|PubMed:17914902, ECO:0000269|PubMed:8809081}; KM=17 mM for uridine (with ATP as cosubstrate) {ECO:0000269|PubMed:17914902, ECO:0000269|PubMed:8809081}; pH dependence: Optimum pH is 6.5-9. {ECO:0000269|PubMed:17914902, ECO:0000269|PubMed:8809081};
Catalytic ActivityATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide.
Catalytic ActivityATP + beta-D-ribosylnicotinate = ADP + nicotinate beta-D-ribonucleotide.
FunctionCatalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3- deazaguanosine. {ECO:0000269|PubMed:15137942}.
PathwayCofactor biosynthesis; NAD(+) biosynthesis.
SimilarityBelongs to the uridine kinase family. NRK subfamily. {ECO:0000305}.
SubunitMonomer. {ECO:0000269|PubMed:8809081}.
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