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MGP005406

UniProt Annotations

Entry Information
Gene Nameacireductone dioxygenase 1
Protein EntryMTND_HUMAN
UniProt IDQ9BV57
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BV57-1; Sequence=Displayed; Name=2; IsoId=Q9BV57-2; Sequence=VSP_015822; Note=No experimental confirmation available.;
Catalytic Activity1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2-oxobutanoate + formate. {ECO:0000255|HAMAP-Rule:MF_03154, ECO:0000269|PubMed:15938715}.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000255|HAMAP-Rule:MF_03154}; Note=Binds 1 Fe cation per monomer. Can also use other divalent metal cations. {ECO:0000255|HAMAP-Rule:MF_03154};
FunctionCatalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. {ECO:0000255|HAMAP- Rule:MF_03154, ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:15938715}.
InteractionP50281:MMP14; NbExp=4; IntAct=EBI-992807, EBI-992788;
PathwayAmino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. {ECO:0000255|HAMAP-Rule:MF_03154}.
Sequence CautionSequence=AAL25800.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD38646.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD96187.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the acireductone dioxygenase (ARD) family. {ECO:0000255|HAMAP-Rule:MF_03154}.
Subcellular LocationCytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
SubunitMonomer (By similarity). Interacts with MMP14. {ECO:0000255|HAMAP-Rule:MF_03154, ECO:0000269|PubMed:14718544}.
Tissue SpecificityDetected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:14718544}.
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