MGP Database

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MGP005465

UniProt Annotations

Entry Information
Gene NameLIM and senescent cell antigen-like domains 2
Protein EntryLIMS2_HUMAN
UniProt IDQ7Z4I7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; Synonyms=LIM-like protein 2B; IsoId=Q7Z4I7-1; Sequence=Displayed; Name=2; Synonyms=LIM-like protein 2A; IsoId=Q7Z4I7-2; Sequence=VSP_021917; Name=3; Synonyms=LIM-like protein 2C; IsoId=Q7Z4I7-3; Sequence=VSP_021916; Name=4; IsoId=Q7Z4I7-4; Sequence=VSP_045539; Name=5; IsoId=Q7Z4I7-5; Sequence=VSP_046078; Note=No experimental confirmation available.;
FunctionAdapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. {ECO:0000269|PubMed:12167643}.
Sequence CautionSequence=AAM77350.1; Type=Frameshift; Positions=331; Evidence={ECO:0000305};
SimilarityContains 5 LIM zinc-binding domains. {ECO:0000255|PROSITE-ProRule:PRU00125}.
Subcellular LocationNucleus {ECO:0000305}. Cell junction, focal adhesion {ECO:0000269|PubMed:12167643}. Cell membrane {ECO:0000269|PubMed:12167643}; Peripheral membrane protein {ECO:0000269|PubMed:12167643}; Cytoplasmic side {ECO:0000269|PubMed:12167643}.
SubunitInteracts with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS1. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. {ECO:0000250, ECO:0000269|PubMed:12167643, ECO:0000269|PubMed:19963065}.
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