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MGP005519

Record overview

MGPD IDMGP005519
Gene ID55907
SpeciesHomo sapiens (Human)
Gene Namecytidine monophosphate N-acetylneuraminic acid synthetase
Gene Symbol CMAS
SynonymsCSS;
Alternate namesN-acylneuraminate cytidylyltransferase; CMP-N-acetylneuraminic acid synthase; CMP-N-acetylneuraminic acid synthetase; CMP-Neu5Ac synthetase; CMP-NeuNAc synthase; CMP-NeuNAc synthetase; CMP-sialic acid synthetase; cytidine 5'-monophosphate N-acetylneuraminic acid synthetase;
Chromosome12
Map Location12p12.1
EC Number2.7.7.43
SummarySialic acids are a family of nine-carbon sugars on cell surface glycoproteins and glycolipids that play a pivotal role in determining the structure and function of many animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development and N-glycosylation is a common post-translational modification during cellular differentiation. Sialic acids play important roles in cell-cell communications and immune responses. Sialylated glycoprotein and glycolipid formation requires the activation of a sialic acid to a cytidine monophosphate (CMP) diester by the enzyme encoded by this gene: CMP-N-acetylneuraminic acid synthetase. [provided by RefSeq, Jul 2012]
OrthologsView orthologs and multiple alignments for CMAS

Proteins

N-acylneuraminate cytidylyltransferase
Refseq ID:NP_061156
Protein GI:8923900
UniProt ID:Q8NFW8
mRNA ID:NM_018686
Length:434
RefSeq Status:
MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHLAALILARGGSKGIPLKNIKHLAGVPLIGWVLRAALDSGAFQSVWVSTDHDEIENV
AKQFGAQVHRRSSEVSKDSSTSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAK
RPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEI
ISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVSVSDKLAVVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSGAPADACSTAQKA
VGYICKCNGGRGAIREFAEHICLLMEKVNNSCQK
 
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