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MGP005519

UniProt Annotations

Entry Information
Gene Namecytidine monophosphate N-acetylneuraminic acid synthetase
Protein EntryNEUA_HUMAN
UniProt IDQ8NFW8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NFW8-1; Sequence=Displayed; Name=2; IsoId=Q8NFW8-2; Sequence=VSP_012764; Note=No experimental confirmation available.;
Catalytic ActivityCTP + N-acylneuraminate = diphosphate + CMP-N- acylneuraminate. {ECO:0000269|PubMed:11602804}.
DomainThe BC2 (basic cluster 2) motif is necessary and sufficient for the nuclear localization and contains the catalytic active site. The localization in the nucleus is however not required for the enzyme activity (By similarity). {ECO:0000250}.
FunctionCatalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
PathwayAmino-sugar metabolism; N-acetylneuraminate metabolism.
SimilarityBelongs to the CMP-NeuNAc synthase family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:11602804}.
SubunitHomotetramer; the active enzyme is formed by a dimer of dimers.
Tissue SpecificityUbiquitously expressed. Expressed in pancreas, kidney, liver, skeletal muscle, lung, placenta, brain, heart, colon, PBL, small intestine, ovary, testis, prostate, thymus and spleen. {ECO:0000269|PubMed:11602804}.
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