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MGP005543

UniProt Annotations

Entry Information
Gene NameCTP synthase 2
Protein EntryPYRG2_HUMAN
UniProt IDQ9NRF8
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.
FunctionCatalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. {ECO:0000269|PubMed:10899599, ECO:0000269|PubMed:16179339}.
PathwayPyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.
SimilarityBelongs to the CTP synthase family. {ECO:0000305}.
SimilarityContains 1 glutamine amidotransferase type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00605}.
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