MGP Database

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MGP005560

UniProt Annotations

Entry Information
Gene Namesphingosine kinase 2
Protein EntrySPHK2_HUMAN
UniProt IDQ9NRA0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9NRA0-1; Sequence=Displayed; Name=2; IsoId=Q9NRA0-2; Sequence=VSP_006217; Name=3; IsoId=Q9NRA0-3; Sequence=VSP_006217, VSP_006218; Name=4; IsoId=Q9NRA0-4; Sequence=VSP_046910; Note=No experimental confirmation available.; Name=5; IsoId=Q9NRA0-5; Sequence=VSP_047721, VSP_047722;
Biophysicochemical PropertiesKinetic parameters: KM=3.4 uM for sphingosine {ECO:0000269|PubMed:10751414}; pH dependence: Optimum pH is 7.5. {ECO:0000269|PubMed:10751414};
Catalytic ActivityATP + sphinganine = ADP + sphinganine 1- phosphate. {ECO:0000269|PubMed:10751414}.
Catalytic ActivityATP + sphingosine = ADP + sphingosine 1- phosphate. {ECO:0000269|PubMed:10751414}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Enzyme RegulationInhibited by sulfatide. {ECO:0000269|PubMed:19168031}.
FunctionCatalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides. {ECO:0000269|PubMed:19168031}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Subcellular LocationIsoform 1: Cytoplasm. Membrane.
Subcellular LocationIsoform 2: Lysosome membrane.
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