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MGP005570

Record overview

MGPD IDMGP005570
Gene ID56924
SpeciesHomo sapiens (Human)
Gene Namep21 protein (Cdc42/Rac)-activated kinase 6
Gene Symbol PAK6
SynonymsPAK5;
Alternate namesserine/threonine-protein kinase PAK 6; p21(CDKN1A)-activated kinase 6;
Chromosome15
Map Location15q14
EC Number2.7.11.1
SummaryThis gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
OrthologsView orthologs and multiple alignments for PAK6

Proteins

serine/threonine-protein kinase PAK 6 isoform 1
Refseq ID:NP_001122100
Protein GI:191252780
UniProt ID:Q9NQU5
mRNA ID:NM_001128628
Length:681
RefSeq Status:
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTL
RGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQ
SSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP
SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQ
GDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNE
EQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP
YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
 
serine/threonine-protein kinase PAK 6 isoform 1
Refseq ID:NP_001122101
Protein GI:191252782
UniProt ID:Q9NQU5
mRNA ID:NM_001128629
Length:681
RefSeq Status:
Protein sequence is identical to GI:191252780 (mRNA isoform)
 
serine/threonine-protein kinase PAK 6 isoform 1
Refseq ID:NP_064553
Protein GI:9910476
UniProt ID:Q9NQU5
mRNA ID:NM_020168
Length:681
RefSeq Status:
Protein sequence is identical to GI:191252780 (mRNA isoform)
 
serine/threonine-protein kinase PAK 6 isoform 1
Refseq ID:NP_001263646
Protein GI:456367259
UniProt ID:Q9NQU5
mRNA ID:NM_001276717
Length:681
RefSeq Status:
Protein sequence is identical to GI:191252780 (mRNA isoform)
 
serine/threonine-protein kinase PAK 6 isoform 2
Refseq ID:NP_001263647
Protein GI:456367261
UniProt ID:Q9NQU5
mRNA ID:NM_001276718
Length:636
RefSeq Status:
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTL
RGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQ
SSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP
SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQ
GDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNE
EQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVSPVLRDFLERMLVRDPQE
RATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
 
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