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MGP005570

UniProt Annotations

Entry Information
Gene Namep21 protein (Cdc42/Rac)-activated kinase 6
Protein EntryPAK6_HUMAN
UniProt IDQ9NQU5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NQU5-1; Sequence=Displayed; Name=2; IsoId=Q9NQU5-2; Sequence=VSP_056733;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
FunctionSerine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.
InteractionQ5S007:LRRK2; NbExp=2; IntAct=EBI-1053685, EBI-5323863;
PtmAutophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation. {ECO:0000269|PubMed:15550393, ECO:0000269|Ref.12}.
SimilarityBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. {ECO:0000305}.
SimilarityContains 1 CRIB domain. {ECO:0000255|PROSITE- ProRule:PRU00057}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationCytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
SubunitInteracts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1 (By similarity). Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B. {ECO:0000250, ECO:0000269|PubMed:11278661, ECO:0000269|PubMed:11773441, ECO:0000269|PubMed:18642328, ECO:0000269|Ref.13}.
Tissue SpecificitySelectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. {ECO:0000269|PubMed:11278661, ECO:0000269|PubMed:11773441}.
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