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MGP005576

UniProt Annotations

Entry Information
Gene NameSET and MYND domain containing 2
Protein EntrySMYD2_HUMAN
UniProt IDQ9NRG4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRG4-1; Sequence=Displayed; Name=2; IsoId=Q9NRG4-2; Sequence=VSP_056005; Note=No experimental confirmation available.;
Catalytic ActivityS-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. {ECO:0000269|PubMed:18065756, ECO:0000269|PubMed:21782458, ECO:0000269|PubMed:21880715}.
FunctionProtein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458, ECO:0000269|PubMed:21880715}.
InductionExpression is repressed by CEBPA. {ECO:0000269|PubMed:17242690}.
SimilarityBelongs to the class V-like SAM-binding methyltransferase superfamily. {ECO:0000255|PROSITE- ProRule:PRU00190}.
SimilarityContains 1 MYND-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00134}.
SimilarityContains 1 SET domain. {ECO:0000255|PROSITE- ProRule:PRU00190}.
Subcellular LocationCytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
SubunitInteracts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1 (By similarity). Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1. {ECO:0000250, ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:18065756, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21724641}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/SMYD2ID47098ch1q32.html";
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