MGP Database

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MGP005586

UniProt Annotations

Entry Information
Gene Namealdo-keto reductase family 1, member B10 (aldose reductase)
Protein EntryAK1BA_HUMAN
UniProt IDO60218
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=600 uM for D,L-glyceraldehyde {ECO:0000269|PubMed:18087047}; KM=0.6 uM for all-trans-retinaldehyde {ECO:0000269|PubMed:18087047}; KM=0.7 uM for 9-cis-retinaldehyde {ECO:0000269|PubMed:18087047};
Enzyme RegulationInhibited by tolrestat. {ECO:0000269|PubMed:18087047}.
FunctionActs as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. {ECO:0000269|PubMed:18087047}.
InteractionQ13085:ACACA; NbExp=4; IntAct=EBI-1572139, EBI-717681;
SimilarityBelongs to the aldo/keto reductase family. {ECO:0000305}.
Subcellular LocationLysosome {ECO:0000269|PubMed:21585341}. Secreted {ECO:0000269|PubMed:21585341}. Note=Secreted through a lysosome-mediated non-classical pathway.
Tissue SpecificityFound in many tissues. Highly expressed in small intestine, colon and adrenal gland.
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